METHAMPHETAMINE-INDUCED CHANGES IN BRAIN CATECHOLAMINES IN RATS AND GUINEA-PIGS

被引：105
|
作者：
WAGNER, GC
SEIDEN, LS
SCHUSTER, CR
机构：
[1] UNIV CHICAGO, DEPT PHARMACOL & PHYSIOL SCI, CHICAGO, IL 60637 USA
[2] UNIV CHICAGO, DEPT PSYCHIAT, CHICAGO, IL 60637 USA
来源：
DRUG AND ALCOHOL DEPENDENCE | 1979年 / 4卷 / 05期
关键词：
D O I：
10.1016/0376-8716(79)90076-0
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
Methamphetamine is a commonly abused drug by humans. Repeated administration of methamphetamine caused long-term changes in caudate dopamine levels in the rat and guinea-pig. Methamphetamine was administered twice a day for 30 days. Two wk following the last injection, the animals were killed and brains assayed for catecholamine content. These long-term depletions of dopamine, when combined with similar observations previously reported in rhesus monkeys, indicate a species generality of the effects of methamphetamine on caudate dopamine levels.
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收藏
页码：435 / 438
页数：4
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