SYNTHESIS OF THE 5-HT1D RECEPTOR AGONIST MK-0462 VIA A PD-CATALYZED COUPLING REACTION

被引：84

作者：

CHEN, CY ^{[1
]}

LIEBERMAN, DR ^{[1
]}

LARSEN, RD ^{[1
]}

REAMER, RA ^{[1
]}

VERHOEVEN, TR ^{[1
]}

REIDER, PJ ^{[1
]}

COTTRELL, IF ^{[1
]}

HOUGHTON, PG ^{[1
]}

机构：

[1] MERCK RES LABS,DEV LABS,HODDESDON EN11 9BU,HERTS,ENGLAND

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 38期

关键词：

D O I：

10.1016/0040-4039(94)88204-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Application of a palladium-catalyzed coupling between 3 and 5a to the synthesis of the novel 5-HT1D receptor agonist MK-0462 (1), a potential anti-migraine drug, is described.

引用

页码：6981 / 6984

页数：4

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