BINGE COCAINE ADMINISTRATION INDUCES A SUSTAINED INCREASE OF PRODYNORPHIN MESSENGER-RNA IN RAT CAUDATE-PUTAMEN

被引：196
作者：
SPANGLER, R
UNTERWALD, EM
KREEK, MJ
机构：
[1] The Biology of Addictive Diseases Laboratory, The Rockefeller University, New York
来源：
MOLECULAR BRAIN RESEARCH | 1993年 / 19卷 / 04期
基金：
美国国家卫生研究院;
关键词：
PRODYNORPHIN MESSENGER RNA; COCAINE; RAT; CAUDATE-PUTAMEN; DOPAMINE; SOLUTION HYBRIDIZATION;
D O I：
10.1016/0169-328X(93)90133-A
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Other workers have established that cocaine injections increase the levels of dynorphin peptides in the caudate putamen and substantia nigra of the rat brain. Using a quantitative solution hybridization protection assay for mRNA, we detected a significant increase in the concentration of prodynorphin mRNA in caudate putamen extracts of rats injected with cocaine following a 'binge' administration pattern designed to mimic human cocaine abuse. Increased prodynorphin mRNA was observed at the earliest time-point studied (50 h) and the lowest dose (10 mg/kg/day) of cocaine tested and persisted through the 14 day period studied. No prodynorphin mRNA was detected in the substantia nigra.
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页码：323 / 327
页数：5
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