DIAGNOSIS OF CARBOHYDRATE-DEFICIENT GLYCOPROTEIN SYNDROME BY MATRIX-ASSISTED LASER-DESORPTION TIME-OF-FLIGHT MASS-SPECTROMETRY

被引：47

作者：

WADA, Y

GU, JG

OKAMOTO, N

INUI, K

机构：

[1] RES INST MATERNAL & CHILD HLTH,IZUMI,OSAKA 59002,JAPAN

[2] OSAKA UNIV,SCH MED,DEPT PAEDIAT,SUITA,OSAKA 565,JAPAN

来源：

BIOLOGICAL MASS SPECTROMETRY | 1994年 / 23卷 / 02期

关键词：

D O I：

10.1002/bms.1200230211

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Serum transferrin from patients with carbohydrate-deficient glycoprotein syndrome was analysed by matrix-assisted laser desorption time-of-flight mass spectrometry (MALDI-TOF mass spectrometry). Abnormal molecular species with a defect of one or two oligosaccharide chains of 2200 Da were clearly identified. MALDI-TOF mass spectrometry will serve to diagnose this aetiologically unknown, metabolic disease.

引用

页码：108 / 109

页数：2

共 11 条

[1] CHANGES IN CARBOHYDRATE-DEFICIENT TRANSFERRIN LEVELS AFTER ALCOHOL WITHDRAWAL
BEHRENS, UJ
WORNER, TM
LIEBER, CS
[J]. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1988, 12 (04) : 539 - 544
[2] MICROHETEROGENEITY OF HUMAN-SERUM TRANSFERRIN - A BIOLOGICAL PHENOMENON STUDIED BY ISOELECTRIC-FOCUSING IN IMMOBILIZED PH GRADIENTS
DEJONG, G
VANEIJK, HG
[J]. ELECTROPHORESIS, 1988, 9 (09) : 589 - 598
[3] HARRISON HH, 1992, CLIN CHEM, V38, P1390
[4] SIALIC ACID-DEFICIENT SERUM AND CEREBROSPINAL-FLUID TRANSFERRIN IN A NEWLY RECOGNIZED GENETIC SYNDROME
JAEKEN, J
VANEIJK, HG
VANDERHEUL, C
CORBEEL, L
EECKELS, R
EGGERMONT, E
[J]. CLINICA CHIMICA ACTA, 1984, 144 (2-3) : 245 - 247
[5] Jaeken J, 1991, ACTA PAEDIATR SC S, V375, P6
[6] DISIALOTRANSFERRIN DEVELOPMENTAL DEFICIENCY SYNDROME
KRISTIANSSON, B
ANDERSSON, M
TONNBY, B
HAGBERG, B
[J]. ARCHIVES OF DISEASE IN CHILDHOOD, 1989, 64 (01) : 71 - 76
[7] TRANSFERRIN PHENOTYPE AND LEVEL OF CARBOHYDRATE-DEFICIENT TRANSFERRIN IN HEALTHY-INDIVIDUALS
STIBLER, H
BORG, S
BECKMAN, G
[J]. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1988, 12 (03) : 450 - 453
[8] CARBOHYDRATE-DEFICIENT SERUM TRANSFERRIN IN A NEW SYSTEMIC HEREDITARY SYNDROME
STIBLER, H
JAEKEN, J
[J]. ARCHIVES OF DISEASE IN CHILDHOOD, 1990, 65 (01) : 107 - 111
[9] STIBLER H, 1991, ACTA PAEDIATR SC S, V375, P21
[10] STRUCTURE OF SERUM TRANSFERRIN IN CARBOHYDRATE-DEFICIENT GLYCOPROTEIN SYNDROME
WADA, Y
NISHIKAWA, A
OKAMOTO, N
INUI, K
TSUKAMOTO, H
OKADA, S
TANIGUCHI, N
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 189 (02) : 832 - 836

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