Evaluation of Creatinine Clearance in Patients with Obstructive Sleep Apnea Syndrome

Objective: Obstructive sleep apnea syndrome (OSAS) progresses recurrent obstruction in the upper airway during the sleep. It is known that OSAS affects the cardiovascular system and causes hypertension. We aimed to see whether hypertension is an important variable in creatinine clearance estimated by using Cockcroft-Gault formulation in patients with OSAS. Materials and Methods: Thirty-seven (30 male, 7 female) patients with OSAS were included in the study. Cockcroft-Gault formulation was used with the ideal body weight and the correction factor 0.85 was used for females. Patients were divided into two groups; Group I: patients with hypertension (n=12) and Group II: patients without hypertension (n=25). Serum urea, creatinine, sodium, potassium, phosphate, uric acid levels and apnea-hypoapnea index (AHI) were evaluated. Results: There was no statistical difference in age between the Group I (51.50 +/- 3.75 years) and the Group II (47.84 +/- 8.03 years) (p=0.144). Clearance values of these two groups were 72,30 +/- 9,90 mL/min and 84,33 +/- 16,98 mL/min, respectively; there was a statistical difference between the two groups (p=0.031). Conclusion: In presence of hypertension, there is a decrease in creatinine clearance in patients with OSAS.