NOVEL TYPES OF CYCLONUCLEOSIDES

被引：18

作者：

TRONCHET, JMJ

BENHAMZA, R

BERNARDINELLI, G

GEOFFROY, M

机构：

[1] UNIV GENEVA,DEPT CRYSTALLOG,CH-1211 GENEVA 4,SWITZERLAND

[2] UNIV GENEVA,DEPT PHYS CHEM,CH-1211 GENEVA 4,SWITZERLAND

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 04期

关键词：

D O I：

10.1016/0040-4039(90)87026-V

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reduction of 2′-deoxy-2′-hydroxyiminouridine derivatives led to a "first generation" hydroxylamine (2′deoxy-2′-hydroxyaminouridine 8, mostly arabino configuration) which on treatment with aldehydes afforded the corresponding nitrones 9 which were reduced to "second generation" hydroxylamines 12. The modified nucleosides bearing a hydroxyamino group at the 2′-position, when of arabino configuration underwent conjugate addition onto the uracil ring leading to novel types of cyclonucleosides (3, 5, 10, 13). © 1990.

引用

页码：531 / 534

页数：4

共 14 条

[1]

HALL SR, 1987, XTAL2 2 USERS MANUAL

[2] NUCLEIC-ACID RELATED-COMPOUNDS .43. A CONVENIENT PROCEDURE FOR THE SYNTHESIS OF 2' AND 3'-KETONUCLEOSIDES [J].