BLOOD-PRESSURE MODULATION BY SUBSTANCE-P IN THE RAT NUCLEUS TRACTUS SOLITARIUS

被引：61
作者：
KUBO, T
KIHARA, M
机构：
[1] Department of Pharmacology, Yokohama City University School of Medicine, Yokohama
来源：
BRAIN RESEARCH | 1987年 / 413卷 / 02期
关键词：
Blood pressure; Heart rate; Nucleus tractus solitarius; Rat; Substance P; Substance P antagonist;
D O I：
10.1016/0006-8993(87)91033-X
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Substance P in a dose of 0.1-10 ng injected into the nucleus tractus solitarii (NTS) of the rat caused hypotension, bradycardia and apnea whereas a dose of 100 ng led to no response. A substance P antagonist injected into the NTS abolished the cardiovascular responses to substance P. The antagonist alone increased blood pressure and heart rate. The data suggest a role for substance P in the cardiovascular regulation by the NTS. © 1987.
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收藏
页码：379 / 383
页数：5
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