A Case Report of Antitubercular Drugs Induced Exanthematous Reaction Complicated by Acute Onset Levofloxacin Induced Toxic Epidermal Necrolysis (TEN)

被引：4

作者：

Gajjar, Khushboo ^{[1
]}

Hirapara, Hiren ^{[2
]}

Jaiswal, Chandra Sekhar ^{[3
]}

Barvaliya, Manish ^{[1
]}

Shah, Hita ^{[3
]}

Tripathi, Chandrabhanu Rajkishor ^{[1
]}

机构：

[1] Govt Med Coll & Sir Takhtsinhji Gen Hosp, Dept Pharmacol, Bhavnagar 364001, Gujarat, India

[2] GMERS Med Coll, Dept Pharmacol, Junagadh, Gujarat, India

[3] Govt Med Coll & Sir Takhtsinhji Gen Hosp, Dept Dermatol, Bhavnagar 364001, Gujarat, India

来源：

CURRENT DRUG SAFETY | 2018年 / 13卷 / 01期

关键词：

Exanthematous reaction; levofloxacin; toxic epidermal necrolysis; antituberculer drugs; cutaneous adverse reaction; hypersensitivity;

D O I：

10.2174/1574886311666160427104417

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background: We report a case of 25 years old male patient with antitubercular drugs induced exanthematous reaction and hepatotoxicity that was complicated by levofloxacin induced toxic epidermal necrolysis. The patient was allergic to ciprofloxacin and ofloxacin. Cross reactivity between ciprofloxacin and levofloxacin might be responsible for causing this reaction. Conclusion: Issues of cross sensitivity should be kept in mind and the same class of drugs should strictly be avoided to prevent such complications.

引用

页码：41 / 43

页数：3

共 9 条

[1] Cross sensitivity between ciprofloxacin and levofloxacin for an immediate hypersensitivity reaction [J].

Anovadiya, Ashish P. ;

Barvaliya, Manish J. ;

Patel, Tejas K. ;

Tripathi, C. B. .

JOURNAL OF PHARMACOLOGY & PHARMACOTHERAPEUTICS, 2011, 2 (03) :187-188

[2] TOXIC EPIDERMAL NECROLYSIS INDUCED BY LEVOFLOXACIN [J].

Davila, Galicia ;

Ruiz-Hornillos, Javier ;

Rojas, Patricia ;

De Castro, Francisco ;

Zubeldia, Jose M. .

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2009, 102 (05) :441-442

[3] Toxic epidermal necrolysis: Review of pathogenesis and management [J].

Downey, Andrew ;

Jackson, Chris ;

Harun, Nadia ;

Cooper, Alan .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2012, 66 (06) :995-1003

[4]

Dua Ruchi, 2010, Indian J Tuberc, V57, P53

[5]

French Lars E, 2006, Allergol Int, V55, P9, DOI 10.2332/allergolint.55.9

[6]

Lobera T, 2010, J INVEST ALLERG CLIN, V20, P607

[7] A METHOD FOR ESTIMATING THE PROBABILITY OF ADVERSE DRUG-REACTIONS [J].

NARANJO, CA ;

BUSTO, U ;

SELLERS, EM ;

SANDOR, P ;

RUIZ, I ;

ROBERTS, EA ;

JANECEK, E ;

DOMECQ, C ;

GREENBLATT, DJ .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1981, 30 (02) :239-245

[8]

Schumock G T, 1992, Hosp Pharm, V27, P538

[9] Toxic epidermal necrolysis and intravenous immunoglobulin: A review [J].

Trent, Jennifer ;

Halem, Monica ;

French, Lars E. ;

Kerdel, Francisco .

SEMINARS IN CUTANEOUS MEDICINE AND SURGERY, 2006, 25 (02) :91-93

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