FLICKING THE SWITCHES - PHOSPHORYLATION OF SERINE/THREONINE PROTEIN PHOSPHATASES

被引：61

作者：

BRAUTIGAN, DL

机构：

[1] Center for Cell Signaling, University of Virginia, Charlottesville, VA 22908

来源：

SEMINARS IN CANCER BIOLOGY | 1995年 / 6卷 / 04期

关键词：

SIGNAL TRANSDUCTION; CALCINEURIN; CYCLIN-DEPENDENT KINASE; PROTEIN TYR KINASES; INTRAMOLECULAR;

D O I：

10.1006/scbi.1995.0028

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Signal transduction involves protein phosphorylation and dephosphorylation. To produce both substantial and transient changes requires coordinated and reciprocal regulation of kinases and phosphatases. One mechanism to accomplish this is phosphorylation, and there are now reports of phosphorylation of all the major types of protein Ser/Thr phosphatases. Phosphorylation of type-1 and type-2A phosphatases occurs within characteristic C-terminal sequences and results in the loss of phosphatase activity. The phosphatases catalyse intramolecular dephosphorylation, with a restoration of activity. This property probably accounts for the apparent constitutive activity of phosphatases in cell and tissue extracts. Phosphorylation of phosphatases is a way to flick the activity off and on in cells during the growth cycle and in response to stimuli.

引用

页码：211 / 217

页数：7

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