PREDICTING INTERFERON THERAPY EFFICACY FROM HEPATITIS-C VIRUS GENOTYPE AND RNA TITER

被引：142

作者：

MITA, E ^{[1
]}

HAYASHI, N ^{[1
]}

HAGIWARA, H ^{[1
]}

UEDA, K ^{[1
]}

KANAZAWA, Y ^{[1
]}

KASAHARA, A ^{[1
]}

FUSAMOTO, H ^{[1
]}

KAMADA, T ^{[1
]}

机构：

[1] OSAKA UNIV, SCH MED, DEPT MED 1, SUITA, OSAKA 565, JAPAN

来源：

DIGESTIVE DISEASES AND SCIENCES | 1994年 / 39卷 / 05期

关键词：

HEPATITIS C VIRUS; CHRONIC HEPATITIS C; HCV GENOTYPE; INTERFERON THERAPY;

D O I：

10.1007/BF02087547

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We classified 53 Japanese patients with chronic hepatitis C who were treated with natural interferon-alpha into genotypes and also tested the amounts of hepatitis C virus (HCV) RNA. The rate of the long-term complete response group, whose alanine aminotransferase levels remained within the normal range during the six months after therapy, was significantly higher (P < 0.01) in the type-III patients (4/5, 80.0%) than in type-II patients (4/43, 9.3%). For these long-term complete responders, the amounts of HCV RNA was less than 10(7) copies/ml serum in type-II patients, whereas two type-III patients with relatively high amounts of HCV RNA responded completely. These results confirm that the genotype of HCV is an important factor for predicting the response to interferon therapy. The amounts of HCV RNA can also predict its efficacy in type-II patients.

引用

页码：977 / 982

页数：6

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