REACTIONS OF 16-NITROINDOLENINES OF THE VINCADIFFORMINE TYPE

被引：3
作者：
LEWIN, G
ROLLAND, Y
SCHAEFFER, C
POISSON, J
机构：
[1] IDR SERVIER,F-92150 SURESNES,FRANCE
[2] FAC PHARM CHATENAY MALABRY,CHIM SUBST THERAPEUT NAT LAB,F-92296 CHATENAY MALABRY,FRANCE
来源：
HETEROCYCLES | 1994年 / 38卷 / 11期
关键词：
D O I：
10.3987/COM-94-6815
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reactivity of 16-nitroindolenine (4), a byproduct of the aromatic nitration of vincadifformine (1), has been studied. In TFA 4 yielded 10-nitrovincadifformine (3) whereas acid hydrolytic treatment led to the tetracyclic oxindole structure (8) by cleavage of the 2-16 bond. Reduction of 4 (SnCl2 or hydrogenolysis) allowed recovery of 1 in good yield.
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页码：2401 / 2405
页数：5
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