Asymmetric Addition of Diethyl Zinc to Benzaldehyde Catalyzed by Chiral Diamine Ligand and Ti-diamine Modified Complex Derived from D-mannitol

被引：0

作者：

Al Majid, Abdullah M. A. ^{[1
]}

Al-Hazimi, Hassan M. A. ^{[1
]}

Al-Shammery, Mohammed B. ^{[2
]}

机构：

[1] King Saud Univ, Fac Sci, Chem Dept, POB 2455, Riyadh 11451, Saudi Arabia

[2] Alkharj Univ, Fac Sci & Humanitarian Studies, Alkharj, Saudi Arabia

来源：

JORDAN JOURNAL OF CHEMISTRY | 2010年 / 5卷 / 03期

关键词：

Diazide; Chiral diamine; Ttitanium complex; Diethyl zinc; Benzaldehyde; Asymmetric; Enantioselectivity; Addition;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Modified procedure for preparation of chiral: 3,4-Diazido-1, 2:5, 6-di-O-isopropylidene-Dmannitol from the corresponding bismesylate and new chiral ligand: 3, 4-diamino-1, 2:5, 6-Oisopropylidene-D-mannitol was described. The application of both diamine and Ti-diamine complex as catalysts in enantioselective addition of diethyl zinc to prochiral benzaldehyde was described. High enantioselectivity up to 93% e.e. was achieved. The standard analytical measurements including optical activity of the diazide, diamine and the determination of optical purity of the resulting alcohol were reported. [GRAPHICS]

引用

页码：221 / 230

页数：10

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