DEVELOPMENT OF A NEW CONTROLLED RELEASE THEOPHYLLINE TABLET - INVITRO AND INVIVO STUDIES

被引：5
|
作者：
GEORGARAKIS, M
PANAGOPOULOU, A
HATZIPANTOU, P
ILIOPOULOS, T
KONDYLIS, M
GREKAS, D
机构：
[1] BRISTOL HELLAS LABS,ATHENS,GREECE
[2] ARISTOTELIAN UNIV SALONIKA,SCH MED,MED CLIN 1,GR-54006 SALONIKA,GREECE
来源：
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1990年 / 16卷 / 02期
关键词：
D O I：
10.3109/03639049009114888
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Five formulations of controlled release theophylline tablets, specially shaped to a multi scored approximately rectangular structure, manually dividable accurately and conveniently into bisectional or trisectional subdosage units were prepared, using ethyl cellulose/hydroxypropylcellulose and Eudragit RL. The influence of two parameters (fillers, granulation) on the dissolution rate of all tablets was studied. It was found that granulation yields greater retardation in dissolution rate, in comparison to direct compression. No significant differences were found among the fillers used, concerning the dissolution rate. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
引用
收藏
页码：315 / 329
页数：15
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