A NOVEL METHOD FOR MEASURING MEMBRANE-WATER PARTITION-COEFFICIENTS OF HYDROPHOBIC ORGANIC-CHEMICALS - COMPARISON WITH 1-OCTANOL-WATER PARTITIONING

被引:193
作者
GOBAS, FAPC
LAHITTETE, JM
GAROFALO, G
WAN, YS
MACKAY, D
机构
[1] UNIV TORONTO,DEPT CHEM ENGN & APPL CHEM,TORONTO M5S 1A4,ONTARIO,CANADA
[2] ECOLE NATL SUPER CHIM,F-34075 MONTPELLIER,FRANCE
关键词
D O I
10.1002/jps.2600770317
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:265 / 272
页数:8
相关论文
共 45 条
[21]  
KAMLET MJ, COMMUNICATION
[22]   METHOD FOR MEASURING NONELECTROLYTE PARTITION-COEFFICIENTS BETWEEN LIPOSOMES AND WATER [J].
KATZ, Y ;
DIAMOND, JM .
JOURNAL OF MEMBRANE BIOLOGY, 1974, 17 (01) :69-86
[23]   THERMODYNAMIC CONSTANTS FOR NONELECTROLYTE PARTITION BETWEEN DIMYRISTOYL LECITHIN AND WATER [J].
KATZ, Y ;
DIAMOND, JM .
JOURNAL OF MEMBRANE BIOLOGY, 1974, 17 (02) :101-120
[24]  
KUBINYI H, 1976, ARZNEIMITTEL-FORSCH, V26, P1991
[25]   PARTITION COEFFICIENTS AND THEIR USES [J].
LEO, A ;
HANSCH, C ;
ELKINS, D .
CHEMICAL REVIEWS, 1971, 71 (06) :525-+
[26]   DEPENDENCE OF HYDROPHOBICITY OF APOLAR MOLECULES ON THEIR MOLECULAR VOLUME [J].
LEO, A ;
HANSCH, C ;
JOW, PYC .
JOURNAL OF MEDICINAL CHEMISTRY, 1976, 19 (05) :611-615
[27]   LIPOPHILICITY, MOLECULAR-WEIGHT, AND DRUG-ACTION - REEXAMINATION OF PARABOLIC AND BILINEAR MODELS [J].
LIEN, EJ ;
WANG, PH .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1980, 69 (06) :648-650
[28]  
LIEN EJ, 1985, ENVIRON TOXICOL CHEM, V4, P259
[29]  
LIPNICK RL, 1987, IN PRESS 6TH P EUR Q
[30]   RELATIONSHIPS BETWEEN OCTANOL WATER PARTITION-COEFFICIENT AND AQUEOUS SOLUBILITY [J].
MILLER, MM ;
WASIK, SP ;
HUANG, GL ;
SHIU, WY ;
MACKAY, D .
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 1985, 19 (06) :522-529