Adjuvants to local anaesthetics in regional anaesthesia - Should they be used? Part II: Cons

被引：2

作者：

Biyani, Ghansham ^{[1
]}

Chhabra, Anjolie ^{[1
]}

Baidya, Dalim Kumar ^{[1
]}

机构：

[1] All India Inst Med Sci, Dept Anaesthesiol & Intens Care, New Delhi, India

来源：

TRENDS IN ANAESTHESIA AND CRITICAL CARE | 2014年 / 4卷 / 04期

关键词：

Local anaesthetics; Adjuvants; Regional anaesthesia; Peripheral nerve blockade;

D O I：

10.1016/j.tacc.2014.05.003

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Many drugs used as adjuvants for peripheral nerve blocks may not potentiate the effect of local anaesthetics to produce a clinically significant effect. At times, the side effects caused by the systemic absorption of these drugs outweigh the benefits. Some drugs that have already been in use as adjuvants have subsequently been demonstrated to have neurotoxic potential in animals, but data in humans is lacking. The aim of this article is to bring forth all the available literature as regards the above features with respect to adjuvants such as opioids, clonidine, dexmedetomidine, ketamine, midazolam, magnesium, adenosine, neostigmine and epinephrine which are commonly used with local anaesthetics to enhance the effect of regional nerve blocks. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：91 / 96

页数：6

共 68 条

[31] Phase 2, Double-blind, Placebo-controlled, Dose-Response Trial of Intravenous Adenosine for Perioperative Analgesia [J].

Habib, Ashraf S. ;

Minkowitz, Harold ;

Osborn, Timothy ;

Ogunnaike, Babatunde ;

Candiotti, Keith ;

Viscusi, Eugene ;

Gu, Jiezhun ;

Creed, Mary R. ;

Gan, Tong J. .

ANESTHESIOLOGY, 2008, 109 (06) :1085-1091

[32] Use of intrathecal neostigmine as an adjunct to other spinal medications in perioperative and peripartum analgesia: A meta-analysis [J].

Ho, KM ;

Ismail, H ;

Lee, KC ;

Branch, R .

ANAESTHESIA AND INTENSIVE CARE, 2005, 33 (01) :41-53

[33]

Jadon A, 2009, J ANAESTHESIOL CLIN, V25, P207

[34] Clonidine administered as adjuvant for bupivacaine in ilioinguinal-iliohypogastric nerve block does not prolong postoperative analgesia [J].

Kaabachi, O ;

Zerelli, Z ;

Methamem, M ;

Ben Abdelaziz, A ;

Moncer, K ;

Toumi, M .

PEDIATRIC ANESTHESIA, 2005, 15 (07) :586-590

[35] Tramadol as an Adjuvant to Lidocaine for Axillary Brachial Plexus Block [J].

Kaabachi, Olfa ;

Ouezini, Rami ;

Koubaa, Walid ;

Ghrab, Badii ;

Zargouni, Amin ;

Ben Abdelaziz, Ahmed .

ANESTHESIA AND ANALGESIA, 2009, 108 (01) :367-370

[36] Tramadol does not prolong the effect of ropivacaine 7.5 mg/ml for axillary brachial plexus block [J].

Kesimci, E. ;

Izdes, S. ;

Gozdemir, M. ;

Kanbak, O. .

ACTA ANAESTHESIOLOGICA SCANDINAVICA, 2007, 51 (06) :736-741

[37]

Kohli Santvana, 2013, J Anaesthesiol Clin Pharmacol, V29, P491, DOI 10.4103/0970-9185.119147

[38] Efficacy of stellate ganglion block with an adjuvant ketamine for peripheral vascular disease of the upper limbs [J].

Kulkarni, Kalpana R. ;

Kadam, Anita I. ;

Namazi, Ismile J. .

INDIAN JOURNAL OF ANAESTHESIA, 2010, 54 (06) :546-551

[39] Tramadol Added to Bupivacaine Does Not Prolong Analgesia of Continuous Psoas Compartment Block [J].

Kumar, Mukesh ;

Batra, Yatindra Kumar ;

Panda, Nidhi Bidyut ;

Rajeev, Subramanyam ;

Nagi, Onkar Nath .

PAIN PRACTICE, 2009, 9 (01) :43-50

[40] Lessons from spinal midazolam: When misuse of messages from preclinical models exposes patients to unnecessary risks [J].

Lavand'homme, Patricia .

REGIONAL ANESTHESIA AND PAIN MEDICINE, 2006, 31 (06) :489-491

← 1 2 3 4 5 6 7 →