SELECTIVE DOPAMINE D-1-RECEPTOR AGONISTS, SK-AND-F-38393 AND CY-208-243 REDUCE SUCROSE SHAM-FEEDING IN THE RAT

被引：16

作者：

COOPER, SJ

FRANCIS, J

BARBER, DJ

机构：

[1] Laboratory of Psychopharrmacology, School of Psychology, University of Birmingham, Birmingham

来源：

NEUROPHARMACOLOGY | 1993年 / 32卷 / 01期

关键词：

DOPAMINE D-1-RECEPTOR; CY-208-243; SK-AND-F-38393; SUCROSE SHAM-FEEDING;

D O I：

10.1016/0028-3908(93)90135-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Gastric-fistulated rats were trained to sham-feed a 10% sucrose solution in a 60 min test. The selective dopamine D-1 receptor agonists, SK&F 38393 (3 and 10 mg/kg, s.c.) and CY 208-243 (I and 3 mg/kg, s.c.) both produced dose-related reductions in sham-feeding. These effects were present in the first 5 min of the test period, and persisted throughout the remainder of the test. The data confirm and extend results for an anorectic effect of SK&F 38393 and demonstrate, for the first time, a similar anorectic effect of CY 208-243.

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页码：101 / 102

页数：2

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