REVIEW OF THE APPLICATIONS OF PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING

被引：163

作者：

HIMMELSTEIN, KJ ^{[1
]}

LUTZ, RJ ^{[1
]}

机构：

[1] NIH,BIOMED & INSTRUMENTAT BRANCH,BETHESDA,MD 20014

来源：

JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS | 1979年 / 7卷 / 02期

关键词：

actinomycin D; adriamycin; araC; blood flow; cephalosporin; cytarabine; flow-limited model; lidocaine; mercaptopurine; methotrexate; physiological modeling; salicylate; sulfobromophthalein; thiopental;

D O I：

10.1007/BF01059734

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The physiological pharmacokinetic approach to the modeling of drug distribution is reviewed. These models allow extrapolation outside the range of data with some confidence if the dominant mechanisms of transport are sufficiently well understood. In addition, it is possible to extrapolate to other species. Compartments correspond to anatomical spaces so that biochemical interactions (including drug effect or pharmacodynamics) can be incorporated in the model. The articles summarized in this review are limited to models dealing with drug application. © 1979 Plenum Publishing Corporation.

引用

页码：127 / 145

页数：19

共 28 条

[1]

BENOWITZ N, 1974, CLIN PHARMACOL THER, V16, P87

[2] THIOPENTAL PHARMACOKINETICS [J].