Methods of Synthesis, Properties and Biomedical Applications of CuO Nanoparticles

被引:300
作者
Grigore, Madalina Elena [1 ]
Biscu, Elena Ramona [1 ]
Holban, Alina Maria [2 ,3 ]
Gestal, Monica Cartelle [4 ]
Grumezescu, Alexandru Mihai [2 ]
机构
[1] Univ Politehn Bucuresti, Fac Med Engn, Dept Biomat & Med Devices, Bucharest 060042, Romania
[2] Univ Bucharest ICUB, Res Inst, Div Earth Environm & Life Sci, Bucharest 060042, Romania
[3] Univ Politehn Bucuresti, Fac Appl Chem & Mat Sci, Dept Sci & Engn Oxide Mat & Nanomat, Bucharest 060042, Romania
[4] Univ Georgia Athens, Coll Vet Med, Dept Infect Dis, Athens, GA 30602 USA
关键词
CuO; antimicrobial nanoparticles; synthesis; biomedical nanostructures;
D O I
10.3390/ph9040075
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
This study aims to provide an updated survey of the main synthesis methods of copper oxide (CuO) nanoparticles in order to obtain tailored nanosystems for various biomedical applications. The synthesis approach significantly impacts the properties of such nanoparticles and these properties in turn have a significant impact on their biomedical applications. Although not widely investigated as an efficient drug delivery system, CuO nanoparticles have great biological properties including effective antimicrobial action against a wide range of pathogens and also drug resistant bacteria. These properties have led to the development of various approaches with direct applications to the biomedical field, such as tailored surfaces with antimicrobial effect, wound dressings and modified textiles. It is also believed that these nanosystems could represent efficient alternatives in the development of smart systems utilized both for the detection of pathogens and for the treatment of infections.
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页数:14
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