DRUG ERUPTION CAUSED BY RECOMBINANT HUMAN G-CSF

被引：5

作者：

SASAKI, O ^{[1
]}

YOKOYAMA, A ^{[1
]}

UEMURA, S ^{[1
]}

FUJINO, S ^{[1
]}

INOUE, Y ^{[1
]}

KOHNO, N ^{[1
]}

HIWADA, K ^{[1
]}

机构：

[1] EHIME UNIV,SCH MED,DEPT INTERNAL MED 2,SHIGENOBU,EHIME 79102,JAPAN

来源：

INTERNAL MEDICINE | 1994年 / 33卷 / 10期

关键词：

INTRADERMAL TEST; NEUTROPENIA;

D O I：

10.2169/internalmedicine.33.641

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Two types of recombinant human granulocyte colony-stimulating factor (rhG-CSF) are available, and equally used for mitigation of neutropenia. One is a glycosylated natural product from mammalian cells, and the other a non-glycosylated form from Escherichia coli. Though only minimal adverse effects have been reported for both, we treated two patients with rhG-CSF-induced systemic eruption. Based on these patients, the following should be noted: 1) drug eruption may occur in both types of rhG-CSF without detectable antibodies, 2) intradermal test is useful for determination of the causal drug, and 3) if one rhG-CSF product causes eruption, the alternative one may possibly be safe and effective.

引用

页码：641 / 643

页数：3

共 8 条

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