Action Mechanisms of MicroRNAs in Gastric Cancer and its Application in Translational Medicine

Translational medicine is a new concept proposed in the field of international medicine and emphasizes a two-sided way from bench to beside and from beside to bench. Gastric cancer is a commonly encountered malignant tumor in the digestive system all over the world, with high morbidity and mortality. Although its incidence is decreasing, the outcomes of this disease are among the poorest in all solid tumors. Therefore, it is very urgent to seek new preventive and therapeutic targets for gastric cancer and to make basic research results apply in clinic. MicroRNAs (miRNAs) are a classification of endogenous non-coding RNA with the function of regulating the expression of target genes. More and more studies have revealed that miRNAs are intimately associated with the occurrence, development, treatment and prognosis of gastric cancer. Therefore, this review provides an overview of the effects of miRNAs in gastric cancer on the cell cycle, apoptosis, invasion, metastasis, radiosensitivity and chemosensitivity.