CHRONIC EFFECTS OF TERTATOLOL ON RENAL-FUNCTION IN HYPERTENSIVE PATIENTS WITH MILD CHRONIC-RENAL-FAILURE

被引:6
作者
HANNEDOUCHE, T
BROUARD, R
GODIN, M
KLEINKNECHT, D
PAILLARD, F
GRUNFELD, JP
机构
[1] HOP BOIS GUILLAUME,ROUEN,FRANCE
[2] HOP INTERCOMMUNAL MONTREUIL,MONTREUIL,FRANCE
[3] IRIS CD,COURBEVOIE,FRANCE
[4] HOP TENON,F-75970 PARIS 20,FRANCE
关键词
BETA-BLOCKER; HYPERTENSION; RENAL HEMODYNAMICS; RENAL FAILURE; TERTATOLOL;
D O I
10.1093/ndt/6.4.252
中图分类号
R3 [基础医学]; R4 [临床医学];
学科分类号
1001 ; 1002 ; 100602 ;
摘要
To assess the potential benefit of drug-induced renal haemodynamic changes in patients with chronic renal failure, we have evaluated the effects of the beta-blocking agent tertatolol on blood pressure, glomerular filtration rate, and renal plasma flow. Inulin and PAH clearances were performed before and after 3 months treatment and oral tertatolol, 5 mg daily in eight hypertensive patients with moderate chronic renal failure. After 3 months of treatment, glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) increased significantly by 10% and 13% respectively, whereas renal vascular resistance decreased by 16% and the filtration fraction was unchanged. These results indicate that tertatolol possesses novel renal haemodynamic properties in hypertensive patients with chronic renal failure. However, the long-term benefit of such a therapy is yet to be confirmed.
引用
收藏
页码:252 / 256
页数:5
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