MODIFICATION OF DOPAMINERGIC RECEPTOR SENSITIVITY IN RAT-BRAIN AFTER AMYGDALOID KINDLING

被引：33

作者：

GEE, KW

HOLLINGER, MA

BOWYER, JF

KILLAM, EK

机构：

[1] Department of Pharmacology, School of Medicine, University of California, Davis

来源：

EXPERIMENTAL NEUROLOGY | 1979年 / 66卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0014-4886(79)90220-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alterations in dopaminergic receptor sensitivity in various brain areas have been demonstrated in the rat after the kindling of seizures by repeated amygdala stimulation. Using a radioligand binding assay with [3H]spiroperidol as the ligand and butaclamol as the specific antagonist in crude brain homogenates, high- and low-affinity receptor sites have been shown to be differentially affected in various brain areas with respect to both density of sites and affinity for ligand. © 1979.

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收藏

页码：771 / 777

页数：7

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