MODIFICATION OF DOPAMINERGIC RECEPTOR SENSITIVITY IN RAT-BRAIN AFTER AMYGDALOID KINDLING

被引：33
作者：
GEE, KW
HOLLINGER, MA
BOWYER, JF
KILLAM, EK
机构：
[1] Department of Pharmacology, School of Medicine, University of California, Davis
来源：
EXPERIMENTAL NEUROLOGY | 1979年 / 66卷 / 03期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/0014-4886(79)90220-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Alterations in dopaminergic receptor sensitivity in various brain areas have been demonstrated in the rat after the kindling of seizures by repeated amygdala stimulation. Using a radioligand binding assay with [3H]spiroperidol as the ligand and butaclamol as the specific antagonist in crude brain homogenates, high- and low-affinity receptor sites have been shown to be differentially affected in various brain areas with respect to both density of sites and affinity for ligand. © 1979.
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收藏
页码：771 / 777
页数：7
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