LC-MS-based metabolomics in profiling of drug metabolism and bioactivation

被引：36

作者：

Li, Feng ^{[1
]}

Gonzalez, Frank J. ^{[2
]}

Ma, Xiaochao ^{[1
]}

机构：

[1] Univ Kansas, Med Ctr, Dept Pharmacol Toxicol & Therapeut, Kansas City, KS 66160 USA

[2] NCI, Lab Metab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

ACTA PHARMACEUTICA SINICA B | 2012年 / 2卷 / 02期

关键词：

Metabolomics; Drug metabolism; Reactive metabolitics; Multivariate data analyst;

D O I：

10.1016/j.apsb.2012.02.010

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Since metabolism significantly affects drug safety and efficacy, determining the metabolic profile of a drug is a critical part of drug development. The application of an LC MS-based metabolomic approach has gained more widespread use in identifying drug metabolites, developing metabolic maps and lending clues to mechanisms of bioactivation. Thus, the LC MS-based metabolomic approach is a powerful tool for profiling of drug metabolism and bioactivation. (C) 2012 Institute of Materia Medica, Chinese Academy of Medical Sciences and Chinese Pharmaceutical Association. Production and hosting by Elsevier B.V. All rights reserved.

引用

页码：118 / 125

页数：8

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