Enantiodifferentiation of dihydropyridine PAF antagonists

被引：2

作者：

Cooper, K ^{[1
]}

Fray, MJ ^{[1
]}

Parry, MJ ^{[1
]}

Richardson, K ^{[1
]}

Steele, J ^{[1
]}

机构：

[1] PFIZER LTD,SANDWICH,KENT,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 24期

关键词：

D O I：

10.1016/0960-894X(95)00542-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The PAF antagonist activity of a series of enantiomeric dihydropyridines is described. In the first example, 1, the PAF antagonist activity and calcium channel blocking activity reside in opposite enantiomers. Subsequent examples also display enantioselectivity and the SAR of the series is described.

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收藏

页码：3085 / 3090

页数：6

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