CYTOMEGALOVIRUS AS A COFACTOR OF DISEASE PROGRESSION IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION

被引：6

作者：

NARDIELLO, S ^{[1
]}

DIGILIO, L ^{[1
]}

PIZZELLA, T ^{[1
]}

GALANTI, B ^{[1
]}

机构：

[1] SECONDA UNIV NAPOLI,OSPED GESU & MARIA,IST MALATTIE INFETT,CATTEDRA MALATTIE TROP,VIA COTUGNO 1,I-80135 NAPLES,ITALY

来源：

INTERNATIONAL JOURNAL OF CLINICAL & LABORATORY RESEARCH | 1994年 / 24卷 / 02期

关键词：

ACQUIRED IMMUNODEFICIENCY SYNDROME; CYTOMEGALOVIRUS; HUMAN IMMUNODEFICIENCY VIRUS; COFACTORS;

D O I：

10.1007/BF02593905

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cytomegalovirus has been suggested as a co-factor of disease progression in patients with human immunodeficiency virus type 1 infection. Cytomegalovirus infection is highly prevalent among populations at risk of human immunodeficiency virus 1 infection, and has been associated with both an increased susceptibility to infection and a more rapid course of the disease towards immunodeficiency. Cytomegalovirus can have a direct immunosuppressive effect (through infection of immune cells) and can enhance the replication of human immunodeficiency virus (through the transactivation of the genic immunodeficiency virus expression, the stimulation of cytokine production, and the increase in Fc receptor expression on target cells). The role of cytomegalovirus as a co-factor of the progression towards immunodeficiency in subjects infected with the human immunodeficiency virus type 1 needs to be elucidated with more extensive clinical studies and the application of new molecular biology techniques.

引用

页码：86 / 89

页数：4

共 34 条

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