D-ALPHA-TOCOPHEROL INHIBITS LOW-DENSITY-LIPOPROTEIN INDUCED PROLIFERATION AND PROTEIN-KINASE-C ACTIVITY IN VASCULAR SMOOTH-MUSCLE CELLS

被引：82
作者：
OZER, NK
PALOZZA, P
BOSCOBOINIK, D
AZZI, A
机构：
[1] UNIV BERN, INST BIOCHEM & MOLEK BIOL, BUHLSTR 28, CH-3012 BERN, SWITZERLAND
[2] MARMARA UNIV, FAC MED, DEPT BIOCHEM, 81326 HAYDARPASA, TURKEY
[3] UNIV CATTOLICA SACRO CUORE, IST PATOL GEN, I-00168 ROME, ITALY
来源：
FEBS LETTERS | 1993年 / 322卷 / 03期
关键词：
SMOOTH MUSCLE CELL PROLIFERATION; D-ALPHA-TOCOPHEROL; ARTERIOSCLEROSIS; LOW DENSITY LIPOPROTEIN;
D O I：
10.1016/0014-5793(93)81592-N
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Native and malondialdehyde modified low density lipoproteins have been shown to stimulate smooth muscle cell proliferation (A7r5) in vitro. The stimulation is associated with an increase of protein kinase C activity. d-alpha-Tocopherol, at physiological concentrations, has been found to inhibit both protein kinase C activity and cell proliferation.
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收藏
页码：307 / 310
页数：4
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