D-ALPHA-TOCOPHEROL INHIBITS LOW-DENSITY-LIPOPROTEIN INDUCED PROLIFERATION AND PROTEIN-KINASE-C ACTIVITY IN VASCULAR SMOOTH-MUSCLE CELLS

被引：82
作者：
OZER, NK
PALOZZA, P
BOSCOBOINIK, D
AZZI, A
机构：
[1] UNIV BERN, INST BIOCHEM & MOLEK BIOL, BUHLSTR 28, CH-3012 BERN, SWITZERLAND
[2] MARMARA UNIV, FAC MED, DEPT BIOCHEM, 81326 HAYDARPASA, TURKEY
[3] UNIV CATTOLICA SACRO CUORE, IST PATOL GEN, I-00168 ROME, ITALY
来源：
FEBS LETTERS | 1993年 / 322卷 / 03期
关键词：
SMOOTH MUSCLE CELL PROLIFERATION; D-ALPHA-TOCOPHEROL; ARTERIOSCLEROSIS; LOW DENSITY LIPOPROTEIN;
D O I：
10.1016/0014-5793(93)81592-N
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Native and malondialdehyde modified low density lipoproteins have been shown to stimulate smooth muscle cell proliferation (A7r5) in vitro. The stimulation is associated with an increase of protein kinase C activity. d-alpha-Tocopherol, at physiological concentrations, has been found to inhibit both protein kinase C activity and cell proliferation.
引用
收藏
页码：307 / 310
页数：4
相关论文
共 19 条
[1]   A PROTEIN KINASE-C PSEUDOSUBSTRATE PEPTIDE INHIBITS PHOSPHORYLATION OF THE CD3 ANTIGEN IN STREPTOLYSIN-O-PERMEABILIZED HUMAN LYMPHOCYTES-T [J].
ALEXANDER, DR ;
HEXHAM, JM ;
LUCAS, SC ;
GRAVES, JD ;
CANTRELL, DA ;
CRUMPTON, MJ .
BIOCHEMICAL JOURNAL, 1989, 260 (03) :893-901
[2]   THE PROTEIN-KINASE-C FAMILY [J].
AZZI, A ;
BOSCOBOINIK, D ;
HENSEY, C .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1992, 208 (03) :547-557
[3]  
AZZI A, 1993, IN PRESS OXIDATIVE S
[4]   PHOSPHOINOSITIDE AND CALCIUM SIGNALING RESPONSES IN SMOOTH-MUSCLE CELLS - COMPARISON BETWEEN LIPOPROTEINS, ANG-II, AND PDGF [J].
BOCHKOV, V ;
TKACHUK, V ;
BUHLER, F ;
RESINK, T .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 188 (03) :1295-1304
[5]   ALPHA-TOCOPHEROL (VITAMIN-E) REGULATES VASCULAR SMOOTH-MUSCLE CELL-PROLIFERATION AND PROTEIN-KINASE-C ACTIVITY [J].
BOSCOBOINIK, D ;
SZEWCZYK, A ;
AZZI, A .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1991, 286 (01) :264-269
[6]  
BOSCOBOINIK D, 1991, J BIOL CHEM, V266, P6188
[7]  
BUHLER FR, 1991, J HYPERTENS, V9, pS28
[8]  
CHATELAIN E, 1993, IN PRESS BIOCH BIOPH
[9]  
CHUNG BH, 1986, METHOD ENZYMOL, V128, P181
[10]   MALONDIALDEHYDE ALTERATION OF LOW-DENSITY LIPOPROTEINS LEADS TO CHOLESTERYL ESTER ACCUMULATION IN HUMAN MONOCYTE-MACROPHAGES [J].
FOGELMAN, AM ;
SHECHTER, I ;
SEAGER, J ;
HOKOM, M ;
CHILD, JS ;
EDWARDS, PA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (04) :2214-2218
12