NOVEL EFFECT OF AZIDE ON SODIUM-CHANNEL OF XENOPUS OOCYTES

被引：10

作者：

ANDO, H

机构：

[1] Department of Physiology, Kobe University School of Medicine, Kobe

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 172卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(05)80209-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bath application of a few mM of sodium azide to a voltage clamped oocyte activated a voltage dependent Na+ current. Characteristics of the azide-induced current were the same as those of already described Na+ current induced by prolonged depolarization. The Na+ current induced either by azide or depolarization was suppressed by the application of Ca2+ channel blockers (Diltiazem and La3+). Azide is known to affect some metabolic processes (ATP and cGMP production etc.), but the present effect could not be attributed to metabolic actions. © 1990 Academic Press, Inc.

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页码：300 / 305

页数：6

相关论文

共 13 条

[1] SODIUM-CHANNELS INDUCED BY DEPOLARIZATION OF THE XENOPUS-LAEVIS OOCYTE [J].

BAUD, C ;

KADO, RT ;

MARCHER, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (10) :3188-3192

[2] INDUCTION AND DISAPPEARANCE OF EXCITABILITY IN THE OOCYTE OF XENOPUS-LAEVIS - A VOLTAGE-CLAMP STUDY [J].

BAUD, C ;

KADO, RT .

JOURNAL OF PHYSIOLOGY-LONDON, 1984, 356 (NOV) :275-289

[3] DETERMINATION OF IONIC PERMEABILITY COEFFICIENTS OF THE PLASMA-MEMBRANE OF XENOPUS-LAEVIS OOCYTES UNDER VOLTAGE CLAMP [J].

COSTA, PF ;

EMILIO, MG ;

FERNANDES, PL ;

FERREIRA, HG ;

FERREIRA, KG .

JOURNAL OF PHYSIOLOGY-LONDON, 1989, 413 :199-211

[4]

DOULL J, 1980, TOXICOLOGY, P181

[5]

GALLEMORE RP, 1989, J NEUROSCI, V9, P1977

[6] MECHANISMS OF AZIDE INDUCED INCREASES IN THE C-WAVE AND STANDING POTENTIAL OF THE INTACT CAT EYE [J].

LINSENMEIER, RA ;

STEINBERG, RH .

VISION RESEARCH, 1987, 27 (01) :1-8

[7] A CALCIUM-DEPENDENT TRANSIENT OUTWARD CURRENT IN XENOPUS-LAEVIS OOCYTES [J].

MILEDI, R .

PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1982, 215 (1201) :491-497

[8] MEMBRANE CURRENTS ELICITED BY DIVALENT-CATIONS IN XENOPUS OOCYTES [J].

MILEDI, R ;

PARKER, I ;

WOODWARD, RM .

JOURNAL OF PHYSIOLOGY-LONDON, 1989, 417 :173-195

[9]

Murad F, 1978, Adv Cyclic Nucleotide Res, V9, P145

[10] AZIDE-SENSITIVE POTENTIAL DIFFERENCE ACROSS THE EYE-BULB [J].

NOELL, WK .

AMERICAN JOURNAL OF PHYSIOLOGY, 1952, 170 (01) :217-238