ALLYLIC ESTERS AS POTENTIAL ANTI-TUMOR AGENTS - DERIVATIVES AND ANALOGS OF 2,3-BIS(HYDROXYMETHYL)-7-OXABICYCLO[2.2.1]HEPT-2-ENE

被引：12

作者：

ANDERSON, WK

DEWEY, RH

MULUMBA, B

机构：

[1] Department of Medicinal Chemistry, School of Pharmacy, State University of New York at Buffalo, Amherst

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1979年 / 22卷 / 10期

关键词：

D O I：

10.1021/jm00196a024

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Derivatives and analogues of 2, 3-bis(hydroxymethyl)-7-oxabicyclo[2.2.1]hept-2-ene were synthesized. Of the compounds prepared, dimethyl 2, 3-bis(acetoxymethyl)-7-oxabicyclo[2.2.1]hepta-2, 5-diene-5, 6-dicarboxylate (5) was the most potent in a leukemia L1210 tissue culture assay (93% inhibition at 10-6 M). None of the compounds showed significant reproducible in vivo antileukemic activity. © 1979, American Chemical Society. All rights reserved.

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页码：1270 / 1272

页数：3

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