THE RESPONSE TO OVARIAN HYPERSTIMULATION AND INVITRO FERTILIZATION IN WOMEN OLDER THAN 35 YEARS

被引：16

作者：

SEGAL, S ^{[1
]}

CASPER, RF ^{[1
]}

机构：

[1] UNIV TORONTO,DEPT OBSTET & GYNAECOL,DIV REPROD SCI,TORONTO M5S 1A1,ONTARIO,CANADA

来源：

HUMAN REPRODUCTION | 1990年 / 5卷 / 03期

基金：

英国医学研究理事会;

关键词：

Age; Follicle stimulation; IVF;

D O I：

10.1093/oxfordjournals.humrep.a137083

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

There are conflicting reports concerning the effect of female age and potential reproductive function. We assessed the response to ovarian hyperstimulation in two consecutive FVF cycles in 25 women >35 years of age and compared their response to a control group of 48 women <35 years of age who conceived in our IVF programme. In the older women, the maximal oestradiol response was proportional to the number of vials of HMG used and did not differ from the response of the younger women. Similarly, the number of follicles of diameter >1.0 cm, the number of oocytes recovered and the number of embryos which cleaved did not differ between the older and the younger women. However, conception rates were markedly lower in the older women than the overall pregnancy rate in the FVF programme during the same time period. We conclude that the older women in this study have a normal response to ovarian stimulation but may have a decreased receptivity of the endometrium or increased numbers of embryos with chromosomal abnormalities, leading to a reduced rate of implantation. © 1990 Oxford University Press.

引用

页码：255 / 257

页数：3

共 16 条

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