Dickkopfs and Wnt/beta-catenin signalling in liver cancer

被引:48
作者
Fatima, Sarwat [1 ]
Lee, Nikki P. [1 ]
Luk, John M. [2 ,3 ,4 ]
机构
[1] Univ Hong Kong, Dept Surg, Hong Kong, Hong Kong, Peoples R China
[2] Natl Univ Hlth Syst, Dept Pharmacol & Surg, Singapore 117597, Singapore
[3] Natl Univ Singapore, Canc Sci Inst Singapore, Singapore 117456, Singapore
[4] ASTAR, Inst Mol & Cell Biol, Singapore 138673, Singapore
关键词
Dickkopf; Hepatocellular carcinoma; Tumourigenesis; Wnt/beta-catenin signalling;
D O I
10.5306/wjco.v2.i8.311
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Liver cancer is the fifth and seventh most common cause of cancer in men and women, respectively. Wnt/beta-catenin signalling has emerged as a critical player in both the development of normal liver as well as an oncogenic driver in hepatocellular carcinoma (HCC). Based on the current understanding, this article summarizes the possible mechanisms for the aberrant activation of this pathway with specific focus on HCC. Furthermore, we will discuss the role of dickkopfs (DKKs) in regulating Wnt/beta-catenin signalling, which is poorly understood and understudied. DKKs are a family of secreted proteins that comprise at least four members, namely DKK1-DKK4, which act as inhibitors of Wnt/beta-catenin signalling. Nevertheless, not all members antagonize Wnt/beta-catenin signalling. Their functional significance in hepatocarcinogenesis remains to be further characterized for which these studies should provide new insights into the regulatory role of DKKs in Wnt/beta-catenin signalling in hepatic carcinogenesis. Because of the important oncogenic roles, there are an increasing number of therapeutic molecules targeting beta-catenin and the Wnt/beta-catenin pathway for potential therapy of HCC. (C) 2011 Baishideng. All rights reserved.
引用
收藏
页码:311 / 325
页数:15
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