Nanobubbles: a promising efficient tool for therapeutic delivery

被引：113
作者：
Cavalli, Roberta [1 ]
Soster, Marco [1 ]
Argenziano, Monica [1 ]
机构：
[1] Univ Turin, Dept Drug Sci & Technol, Via Pietro Giuria 9, I-10125 Turin, Italy
来源：
THERAPEUTIC DELIVERY | 2016年 / 7卷 / 02期
关键词：
acoustic droplet vaporization; Laplace pressure; nanobubbles; nanomedicine; ultrasound-triggered drug delivery;
D O I：
10.4155/tde.15.92
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In recent decades ultrasound-guided delivery of drugs loaded on nanocarriers has been the focus of increasing attention to improve therapeutic treatments. Ultrasound has often been used in combination with microbubbles, micron-sized spherical gas-filled structures stabilized by a shell, to amplify the biophysical effects of the ultrasonic field. Nanometer size bubbles are defined nanobubbles. They were designed to obtain more efficient drug delivery systems. Indeed, their small sizes allow extravasation from blood vessels into surrounding tissues and ultrasound-targeted site-specific release with minimal invasiveness. Additionally, nanobubbles might be endowed with improved stability and longer residence time in systemic circulation. This review will describe the physico-chemical properties of nanobubbles, the formulation parameters and the drug loading approaches, besides potential applications as a therapeutic tool.
引用
收藏
页码：117 / 138
页数：22
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