STRUCTURE/ACTIVITY RELATIONSHIP OF SOME NATURAL MONOTERPENES AS ACARICIDES AGAINST PSOROPTES CUNICULI

被引：69

作者：

PERRUCCI, S ^{[1
]}

MACCHIONI, G ^{[1
]}

CIONI, PL ^{[1
]}

FLAMINI, G ^{[1
]}

MORELLI, I ^{[1
]}

机构：

[1] UNIV PISA, DIPARTIMENTO CHIM BIOORGAN, I-56126 PISA, ITALY

来源：

JOURNAL OF NATURAL PRODUCTS | 1995年 / 58卷 / 08期

关键词：

D O I：

10.1021/np50122a018

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The pharmacological activity of many essential oils on a large number of human and animal pathogens, as used in folk medicine, has been confirmed world-wide by several laboratory investigations. Unfortunately, the biological properties of essential oils can be extremely inconsistent because of the variability of their chemical composition. The acaricidal activities of some natural terpenoids, which are the main constituents of several essential oils, were evaluated in vitro against the mange mite (Psorptes cuniculi) of the rabbit, by direct: contact and by inhalation. Because the test components represent different chemical classes (hydrocarbons, alcohols, and phenols, with free and esterified or etherified functional groups), it was also possible to discern in a preliminary fashion a correlation between chemical structure and acaricidal activity. The results obtained suggest: that molecules possessing free alcoholic or phenolic groups showed the most potent acaricidal activity.

引用

页码：1261 / 1264

页数：4

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