USE OF IMMUNOSCINTIGRAPHY IN THE DIAGNOSIS OF FEVER OF UNKNOWN ORIGIN

被引:0
作者
BECKER, W
DOLKEMEYER, U
GRAMATZKI, M
SCHNEIDER, MU
SCHEELE, J
WOLF, F
机构
[1] UNIV ERLANGEN NURNBERG,INST CLIN IMMUNOL,DEPT MED 3,W-8520 ERLANGEN,GERMANY
[2] UNIV ERLANGEN NURNBERG,DEPT MED 1,W-8520 ERLANGEN,GERMANY
[3] UNIV ERLANGEN NURNBERG,DEPT SURG,W-8520 ERLANGEN,GERMANY
来源
EUROPEAN JOURNAL OF NUCLEAR MEDICINE | 1993年 / 20卷 / 11期
关键词
FEVER OF UNKNOWN ORIGIN; IMMUNOSCINTIGRAPHY; TECHNETIUM-99M-ANTI-GRANULOCYTE ANTIBODIES; MONOCLONAL ANTIBODY; LOCALIZATION OF INFECTION;
D O I
暂无
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Fever of unknown origin (FUO) has been defined as an elevation in temperature (38-degrees-C) for at least 2-3 weeks despite intensive investigation. The value of immunoscintigraphy with the technetium-99m-labelled anti-granulocyte antibody anti-NCA-95 (BW 250/183, IgG1) was studied retrospectively in 34 consecutive patients with FUO. Every effort was made to confirm a diagnosis, including methods such as ultrasonography, computed tomography, magnetic resonance imaging, bacteriological tests, surgical intervention and clinical follow-up. In 58.8% of the patients, an infectious cause for the fever was found, in 30.2% of the patients, a benign or malignant haematological disease, pancreatitis or thyrotoxicosis was found. No cause for fever could be found in 11%. The overall diagnostic sensitivity and specificity of immunoscintigraphy for infection were 40% and 92% respectively. The positive predictive value was calculated to be 88% and the negative predictive value was calculated to be 52%. False-negative scans were especially noted in patients with endocarditis, pneumonia and small brain abscesses, where the lesions did not exceed a diameter of 0.5 cm. If patients with endocarditis were excluded, the imaging sensitivity and specificity were increased to 57% and 95%. This study demonstrates that 99mTc-anti-NCA-95 scanning is able to localize infectious causes of FUO, other than endocarditis.
引用
收藏
页码:1078 / 1083
页数:6
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