PH+ ACUTE MYELOGENOUS LEUKEMIA WITH T(711)(P15P15) AND CLONAL EVOLUTION IN RELAPSE AFTER BONE-MARROW TRANSPLANTATION

被引：7

作者：

MIURA, I ^{[1
]}

NISHINARI, T ^{[1
]}

HASHIMOTO, K ^{[1
]}

NIMURA, T ^{[1
]}

TAKATSU, H ^{[1
]}

NIITSU, H ^{[1
]}

HIROKAWA, M ^{[1
]}

KUWAYAMA, A ^{[1
]}

NISHIMURA, S ^{[1
]}

MIURA, AB ^{[1
]}

机构：

[1] YURI KUMIAI GEN HOSP,DIV INTERNAL MED,AKITA,JAPAN

来源：

ACTA HAEMATOLOGICA | 1993年 / 90卷 / 03期

关键词：

BONE MARROW TRANSPLANTATION; PH+ ACUTE MYELOGENOUS LEUKEMIA AML; TRANSLOCATION T(711)(P15P15);

D O I：

10.1159/000204397

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 20-year-old female with Ph+ acute myelogenous leukemia (M2) associated with t(7;11)(p15;p15) is reported. Bone marrow aspirates were hypercellular with leukemic cells including Auer rods. Chromosome analysis showed t(7;11) and the Ph chromosome. After complete remission, normal karyotype was restored. Normal male karyotypic cells replaced the bone marrow following allogeneic bone marrow transplantation from her brother. On day 358, cytogenetic study at relapse revealed 14q+ as an additional change and clearly showed that the abnormal clone was derived from the patient, because metaphases with XX were all of abnormal karyotype and those with XY were normal.

引用

页码：148 / 150

页数：3

共 5 条

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UDERZO, C
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MASERA, G
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[3] Effect of slow lymphocyte recovery and type of graft-versus-host disease prophylaxis on relapse after allogeneic bone marrow transplantation for acute myelogenous leukemia
S Kumar
MG Chen
DA Gastineau
MA Gertz
DJ Inwards
MQ Lacy
A Tefferi
MR Litzow
Bone Marrow Transplantation, 2001, 28 : 951 - 956
[4] Effect of slow lymphocyte recovery and type of graft-versus-host disease prophylaxis on relapse after allogeneic bone marrow transplantation for acute myelogenous leukemia
Kumar, S
Chen, MG
Gastineau, DA
Gertz, MA
Inwards, DJ
Lacy, MQ
Tefferi, A
Litzow, MR
BONE MARROW TRANSPLANTATION, 2001, 28 (10) : 951 - 956
[5] Detection of minimal residual disease in a patient having acute myelogenous leukemia with t(16;21)(p11;q22) treated by allogeneic bone marrow transplantation
Okoshi, Y
Shimizu, S
Kojima, H
Obara, N
Mukai, HY
Komeno, T
Hasegawa, Y
Mori, N
Nagasawa, T
ACTA HAEMATOLOGICA, 2001, 105 (01) : 45 - 48

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