SCHISTOSOMA-MANSONI AND TRICHOBILHARZIA-OCELLATA - COMPARISON OF SECRETED CERCARIAL EICOSANOIDS

被引：29
|
作者：
NEVHUTALU, PA
SALAFSKY, B
HAAS, W
CONWAY, T
机构：
[1] UNIV ILLINOIS,COLL MED,ROCKFORD,IL 61107
[2] UNIV ERLANGEN NURNBERG,INST ZOOL,W-8520 ERLANGEN,GERMANY
[3] NO ILLINOIS UNIV,DEPT BIOL SCI,DE KALB,IL 60115
来源：
JOURNAL OF PARASITOLOGY | 1993年 / 79卷 / 01期
关键词：
D O I：
10.2307/3283293
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Schistosoma mansoni cercarial transformation and early stages of penetration can be correlated to specific eicosanoid products. Cercarial eicosanoids are suggested to play immunoregulatory roles during penetration. We examined production of cercarial eicosanoids by S. mansoni compared with that of the duck parasite Trichobilharzia ocellata after incubation with linoleate. Secretions were separated by reversed-phase high pressure liquid chromatography and also quantified by radioimmunoassay. The 2 parasites, differing in their immune evasion, synthesized the same types of prostaglandins, leucotrienes, and hydroxyeicosatetranoic acids in similar quantities. Eicosanoid fractions of both species also showed a similar inhibition of superoxide production by human neutrophils. The coincidence of eicosanoid production suggests a function of eicosanoids in processes that are similar in both species.
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页码：130 / 133
页数：4
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