S-ANTIGEN UVEITIS IN PRIMATES - A NEW MODEL FOR HUMAN-DISEASE

被引：170
作者：
NUSSENBLATT, RB
KUWABARA, T
DEMONASTERIO, FM
WACKER, WB
机构：
[1] NEI, VIS RES LAB, BETHESDA, MD USA
[2] UNIV LOUISVILLE, DEPT OPHTHALMOL, LOUISVILLE, KY 40208 USA
来源：
ARCHIVES OF OPHTHALMOLOGY | 1981年 / 99卷 / 06期
关键词：
D O I：
10.1001/archopht.1981.03930011090021
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Uveitis was induced in rhesus monkeys immunized with purified retinal S-antigen. Focal retinal and subretinal infiltration, in addition to periphlebitic changes, were observed histologically. Immunized monkeys had similar cell-mediated in vitro immune responses to the S-antigen, as do humans with posterior uveitis. Circulating immune complexes at the time of disease were not detected. This primate model supports the notion that the S-antigen may play a role in human uveitis.
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页码：1090 / 1092
页数：3
相关论文
共 11 条
[1]   IMMUNE-COMPLEXES IN UVEITIS [J].
CHAR, DH ;
STEIN, P ;
MASI, R ;
CHRISTENSEN, M .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 1979, 87 (05) :678-681
[2]  
CHESS L, 1975, J IMMUNOL, V115, P315
[3]  
DIXON WJ, 1951, INTRO STATISTICAL AN, P110
[4]  
HAAKENSTAD AO, 1977, AUTOIMMUNITY, P337
[5]  
LAWLEY TJ, 1979, J IMMUNOL, V123, P1382
[6]   CELLULAR IMMUNE RESPONSIVENESS OF UVEITIS PATIENTS TO RETINAL S-ANTIGEN [J].
NUSSENBLATT, RB ;
GERY, I ;
BALLINTINE, EJ ;
WACKER, WB .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 1980, 89 (02) :173-179
[7]   EXPERIMENTAL ALLERGIC UVEITIS - CLINICOPATHOLOGIC FEATURES ASSOCIATED WITH VARYING DOSES OF S-ANTIGEN [J].
RAO, NA ;
WACKER, WB ;
MARAK, GE .
ARCHIVES OF OPHTHALMOLOGY, 1979, 97 (10) :1954-1958
[8]  
SOBORG M, 1971, IN VITRO METHODS CEL, P289
[9]  
WACKER WB, 1977, J IMMUNOL, V119, P1949
[10]  
WACKER WB, NEW DIRECTIONS OPHTH
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