AN ANTIBIOTIC-RESISTANT EXPERIMENTAL-MODEL OF PSEUDOMONAS OSTEOMYELITIS

被引:14
作者
NELSON, DR
BUXTON, TB
LUU, QN
RISSING, JP
机构
[1] VET ADM MED CTR,INFECT DIS SECT 111G,AUGUSTA,GA 30910
[2] MED COLL GEORGIA,INFECT DIS LAB 111G,AUGUSTA,GA 30912
关键词
D O I
10.1007/BF01643399
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
We report a model of chronic Pseudomonas aeruginosa osteomyelitis in the rat that was reproducible, simple and inexpensive. No promoting agent was required to cause infection. Infected animals yielded consistent pseudomonal colony counts (log): 4.98±0.32 (SD)/g cortical tibia (n=16). The 95% confidence interval of the mean was 4.83 -5.14. The inoculum required to infect 50% of challenged rats (ID50) was log 4.0; the ID 100 was log 6.4. Ceftazidime (50 mg/kg/8 h, subcutaneously), alone and in combination with tobramycin (40 mg/kg/12 h, subcutaneously), produced no significant change in quantitative bacterial count or gross bone pathology when used to treat established disease. © 1990 MMV Medizin Verlag GmbH Müncher.
引用
收藏
页码:246 / 248
页数:3
相关论文
共 13 条
[1]   ORAL CIPROFLOXACIN COMPARED WITH PARENTERAL ANTIBIOTICS IN THE TREATMENT OF OSTEOMYELITIS [J].
GENTRY, LO ;
RODRIGUEZ, GG .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (01) :40-43
[2]  
Hidaka S, 1985, Nihon Seikeigeka Gakkai Zasshi, V59, P429
[3]  
KELLY JP, 1975, CURRENT PRACTICE ORT, P120
[4]  
NEU HC, 1984, REV INFECT DIS, V7, pS778
[5]   OFLOXACIN THERAPY FOR EXPERIMENTAL OSTEOMYELITIS CAUSED BY PSEUDOMONAS-AERUGINOSA [J].
NORDEN, CW ;
NIEDERRITER, K .
JOURNAL OF INFECTIOUS DISEASES, 1987, 155 (04) :823-825
[6]   CIPROFLOXACIN AS THERAPY FOR EXPERIMENTAL OSTEOMYELITIS CAUSED BY PSEUDOMONAS-AERUGINOSA [J].
NORDEN, CW ;
SHINNERS, E .
JOURNAL OF INFECTIOUS DISEASES, 1985, 151 (02) :291-294
[7]   EXPERIMENTAL OSTEOMYELITIS CAUSED BY PSEUDOMONAS-AERUGINOSA [J].
NORDEN, CW ;
KELETI, E .
JOURNAL OF INFECTIOUS DISEASES, 1980, 141 (01) :71-75
[8]   EXPERIMENTAL OSTEOMYELITIS .1. A DESCRIPTION OF MODEL [J].
NORDEN, CW .
JOURNAL OF INFECTIOUS DISEASES, 1970, 122 (05) :410-&
[9]   ESTIMATION OF ENDPOINTS IN BIOLOGICAL-SYSTEMS [J].
OZANNE, G .
COMPUTERS IN BIOLOGY AND MEDICINE, 1984, 14 (04) :377-384
[10]   MODEL OF EXPERIMENTAL CHRONIC OSTEOMYELITIS IN RATS [J].
RISSING, JP ;
BUXTON, TB ;
WEINSTEIN, RS ;
SHOCKLEY, RK .
INFECTION AND IMMUNITY, 1985, 47 (03) :581-586