EFFECT OF METOCLOPRAMIDE ON TRANSMURAL ESOPHAGEAL VARICEAL PRESSURE AND PORTAL BLOOD-FLOW IN CIRRHOTIC-PATIENTS

被引：19

作者：

TARANTO, D ^{[1
]}

SUOZZO, R ^{[1
]}

DESIO, I ^{[1
]}

ROMANO, M ^{[1
]}

CAPORASO, N ^{[1
]}

BLANCO, CD ^{[1
]}

COLTORTI, M ^{[1
]}

机构：

[1] NAPLES UNIV,SCH MED 1,IST MED GEN & METODOL CLIN,I-80138 NAPLES,ITALY

来源：

DIGESTION | 1990年 / 47卷 / 01期

关键词：

METOCLOPRAMIDE; TRANSMURAL ESOPHAGEAL VARICEAL PRESSURE; PORTAL BLOOD FLOW;

D O I：

10.1159/000200477

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

This study was undertaken to evaluate the effect of metoclopramide on transmural oesophageal variceal pressure and portal blood flow in cirrhotic patients. Sixteen cirrhotics were randomly assigned to metoclopramide (10 mg i.v.) or saline. Metoclopramide significantly decreased transmural variceal pressure (15.7 % decrease, p < 0.05 vs. basal value). In order to evaluate if the metoclopramide-induced drop in transmural variceal pressure was due to an effect on portal haemodynamics, we also measured, by means of real time and pulsed Doppler ultrasonography, portal vein diameter, mean velocity of portal flow, and portal venous flow. No significant change was observed before and after metoclopramide. In conclusion, metoclopramide, which increases lower oesophageal sphincter pressure, significantly decreases transmural variceal pressure in cirrhotic patients. However, it does not have any effect on portal haemodynamics.

引用

页码：56 / 60

页数：5

共 12 条

[1] DOMPERIDONE-INDUCED INCREASE IN LOWER ESOPHAGEAL SPHINCTER PRESSURE DOES NOT AFFECT AZYGOUS BLOOD-FLOW IN PATIENTS WITH CIRRHOSIS [J].

BRAILLON, A ;

CAPRONCHIVRAC, D ;

VALLA, D ;

LEE, SS ;

CAPRON, JP ;

LEBREC, D .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1986, 21 (09) :1080-1082

[2]

COHEN S, 1976, GASTROENTEROLOGY, V70, P484

[3]

FEU S, 1988, J HEPATOL S1, V7, pS31

[4]

GILL R W, 1979, Ultrasound in Medicine and Biology, V5, P223, DOI 10.1016/0301-5629(79)90014-0

[5] PHARMACOLOGICAL CONSTRICTION OF THE LOWER ESOPHAGEAL SPHINCTER - A SIMPLE METHOD OF ARRESTING VARICEAL HEMORRHAGE [J].

HOSKING, SW ;

DOSS, W ;

ELZEINY, H ;

ROBINSON, P ;

BARSOUM, MS ;

JOHNSON, AG .

GUT, 1988, 29 (08) :1098-1102

[6]

KLEBER G, 1989, Journal of Hepatology, V9, pS50, DOI 10.1016/0168-8278(89)90276-6

[7] PHARMACOLOGIC INFLUENCE ON ESOPHAGEAL-VARICES - A PRELIMINARY-REPORT [J].

LUNDERQUIST, A ;

ALWMARK, A ;

GULLSTRAND, P ;

HALLANGERAS, M ;

JOELSSON, B ;

OWMAN, T ;

PETTERSSON, KI ;

TRANBERG, KG .

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, 1983, 6 (02) :65-71

[8] EFFECTS OF METOCLOPRAMIDE AND DOMPERIDONE ON AZYGOUS VENOUS-BLOOD FLOW IN PATIENTS WITH CIRRHOSIS AND PORTAL-HYPERTENSION [J].

MASTAI, R ;

GRANDE, L ;

BOSCH, J ;

BRUIX, J ;

RIGAU, J ;

KRAVETZ, D ;

NAVASA, M ;

PERA, C ;

RODES, J .

HEPATOLOGY, 1986, 6 (06) :1244-1247

[9] EFFECT OF LOWER ESOPHAGEAL SPHINCTER ON ESOPHAGEAL-VARICES - A PORTOGRAPHIC STUDY [J].

MISKOWIAK, J ;

BURCHARTH, F ;

JENSEN, LI .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1981, 16 (07) :957-960

[10]

MISKOWIAK J, 1978, LANCET, V2, P1284

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