COMPARISON OF HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH RADIOIMMUNOASSAY FOR THE DETERMINATION OF DOMOIC ACID IN BIOLOGICAL SAMPLES

被引：17
作者：
LAWRENCE, JF
CLEROUX, C
TRUELOVE, JF
机构：
[1] Bureau of Chemical Safety, Food Directorate, Health Protection Branch, Ottawa
来源：
JOURNAL OF CHROMATOGRAPHY A | 1994年 / 662卷 / 01期
关键词：
D O I：
10.1016/0021-9673(94)85307-X
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A reversed-phase liquid chromatographic method employing UV absorption detection at 242 nm was compared to a radioimmunoassay technique for the determination of the marine toxin, domoic acid, in several types of seafood and biological samples. Agreement between the two methods for spiked samples of mussels and rat serum was very good over a range of concentrations of 0.15-7.3 mu g/g domoic acid. Also, a very good correlation was observed between the two methods for naturally incurred residues of domoic acid in razor clams, anchovies and crab meat over a concentration range of 0.6-43 mu g/g domoic acid.
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页码：173 / 177
页数：5
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