机构:
UNIV TEXAS,SW MED CTR,HOWARD HUGHES MED INST,DALLAS,TX 75235UNIV TEXAS,SW MED CTR,HOWARD HUGHES MED INST,DALLAS,TX 75235
SUDHOF, TC
[1
]
NEWTON, CL
论文数: 0引用数: 0
h-index: 0
机构:
UNIV TEXAS,SW MED CTR,HOWARD HUGHES MED INST,DALLAS,TX 75235UNIV TEXAS,SW MED CTR,HOWARD HUGHES MED INST,DALLAS,TX 75235
NEWTON, CL
[1
]
ARCHER, BT
论文数: 0引用数: 0
h-index: 0
机构:
UNIV TEXAS,SW MED CTR,HOWARD HUGHES MED INST,DALLAS,TX 75235UNIV TEXAS,SW MED CTR,HOWARD HUGHES MED INST,DALLAS,TX 75235
ARCHER, BT
[1
]
USHKARYOV, YA
论文数: 0引用数: 0
h-index: 0
机构:
UNIV TEXAS,SW MED CTR,HOWARD HUGHES MED INST,DALLAS,TX 75235UNIV TEXAS,SW MED CTR,HOWARD HUGHES MED INST,DALLAS,TX 75235
USHKARYOV, YA
[1
]
MIGNERY, GA
论文数: 0引用数: 0
h-index: 0
机构:
UNIV TEXAS,SW MED CTR,HOWARD HUGHES MED INST,DALLAS,TX 75235UNIV TEXAS,SW MED CTR,HOWARD HUGHES MED INST,DALLAS,TX 75235
MIGNERY, GA
[1
]
机构:
[1] UNIV TEXAS,SW MED CTR,HOWARD HUGHES MED INST,DALLAS,TX 75235
来源:
EMBO JOURNAL
|
1991年
/
10卷
/
11期
关键词:
CA2+ CHANNEL;
ENDOPLASMIC RETICULUM;
INTRACELLULAR CA2+;
RYANODINE RECEPTOR;
SIGNAL TRANSDUCTION;
D O I:
10.1002/j.1460-2075.1991.tb04882.x
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Inositol 1,4,5-trisphosphate (InsP3) constitutes a major intracellular second messenger that transduces many growth factor and neurotransmitter signals. InsP3 causes the release of Ca2+ from intracellular stores by binding to specific receptors that are coupled to Ca2+ channels. One such receptor from cerebellum has previously been extensively characterized. We have now determined the full structure of a second, novel InsP3 receptor which we refer to as type 2 InsP3 receptor as opposed to the cerebellar type 1 InsP3 receptor. The type 2 InsP3 receptor has the same general structural design as the cerebellar type 1 InsP3 receptor with which it shares 69% sequence identity. Expression of the amino-terminal 1078 amino acids of the type 2 receptor demonstrates high affinity binding of InsP3 to the type 2 receptor with a similar specificity but higher affinity than observed for the type 1 receptor. These results demonstrate the presence of several types of InsP3 receptor in brain and raise the possibility that intracellular Ca2+ signaling may involve multiple pathways with different regulatory properties dependent on different InsP3 receptors.