CENTRAL SEROTONERGIC AGENTS RAISE THE REPETITIVE EXTRA-SYSTOLE THRESHOLD OF THE VULNERABLE PERIOD OF THE CANINE VENTRICULAR MYOCARDIUM

被引：36

作者：

BLATT, CM ^{[1
]}

RABINOWITZ, SH ^{[1
]}

LOWN, B ^{[1
]}

机构：

[1] HARVARD UNIV,SCH PUBL HLTH,DEPT NUTR,CARDIOVASC RES LABS,BOSTON,MA 02115

来源：

CIRCULATION RESEARCH | 1979年 / 44卷 / 05期

关键词：

D O I：

10.1161/01.RES.44.5.723

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Systemic administration of three central serotonergic agents, melatonin, 5-methoxytryptophol, and 6-chloro-2-(1-piperazinyl)-pyrazine (MK-212), produced significant increases in the threshold of the vulnerable period for repetitive electrical activity in the canine cardiac ventricle. MK-212 was effective despite bilateral vagotomy. The specific serotonin antagonist, metergoline, blocked the effect of MK-212 on the threshold. An increase in central serotonergic activity may inhibit the flow of arrhythmogenic sympathetic nerve traffic from the brain to the heart.

引用

页码：723 / 730

页数：8

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