CENTRAL SEROTONERGIC AGENTS RAISE THE REPETITIVE EXTRA-SYSTOLE THRESHOLD OF THE VULNERABLE PERIOD OF THE CANINE VENTRICULAR MYOCARDIUM

被引：36

作者：

BLATT, CM ^{[1
]}

RABINOWITZ, SH ^{[1
]}

LOWN, B ^{[1
]}

机构：

[1] HARVARD UNIV,SCH PUBL HLTH,DEPT NUTR,CARDIOVASC RES LABS,BOSTON,MA 02115

来源：

CIRCULATION RESEARCH | 1979年 / 44卷 / 05期

关键词：

D O I：

10.1161/01.RES.44.5.723

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Systemic administration of three central serotonergic agents, melatonin, 5-methoxytryptophol, and 6-chloro-2-(1-piperazinyl)-pyrazine (MK-212), produced significant increases in the threshold of the vulnerable period for repetitive electrical activity in the canine cardiac ventricle. MK-212 was effective despite bilateral vagotomy. The specific serotonin antagonist, metergoline, blocked the effect of MK-212 on the threshold. An increase in central serotonergic activity may inhibit the flow of arrhythmogenic sympathetic nerve traffic from the brain to the heart.

引用

页码：723 / 730

页数：8

共 35 条

[1] CARDIOVASCULAR EFFECTS OF 5-HYDROXYTRYPTOPHAN IN ANESTHETIZED DOGS [J].

ANTONACCIO, MJ ;

ROBSON, RD .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1973, 25 (06) :495-497

[2]

ANTONACCIO MJ, 1975, ARCH INT PHARMACODYN, V231, P200

[3] BRAIN SEROTONIN CONCENTRATION - ELEVATION FOLLOWING INTRAPERITONEAL ADMINISTRATION OF MELATONIN [J].

ANTONTAY, F ;

CHOU, C ;

ANTON, S ;

WURTMAN, RJ .

SCIENCE, 1968, 162 (3850) :277-+

[4] ACUTE PHARMACOLOGY OF MELATONIN [J].

BARCHAS, J ;

DACOSTA, F ;

SPECTOR, S .

NATURE, 1967, 214 (5091) :919-&

[5] INHIBITION OF EFFERENT SYMPATHETIC-NERVE ACTIVITY BY 5-HYDROXYTRYPTOPHAN AND CENTRALLY ADMINISTERED 5-HYDROXYTRYPTAMINE [J].

BAUM, T ;

SHROPSHIRE, AT .

NEUROPHARMACOLOGY, 1975, 14 (03) :227-233

[6] Physiological and anatomical evidence for the existence of nerve tracts connecting the hypothalamus with spinal sympathetic centres [J].

Beattie, J ;

Brow, GR ;

Long, CNH .

PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-CONTAINING PAPERS OF A BIOLOGICAL CHARACTER, 1930, 106 (744) :253-275

[7] ACUTE BLOOD-PRESSURE ELEVATION AND VENTRICULAR-FIBRILLATION THRESHOLD DURING CORONARY-OCCLUSION AND REPERFUSION IN DOG [J].

BLATT, CM ;

VERRIER, RL ;

LOWN, B .

AMERICAN JOURNAL OF CARDIOLOGY, 1977, 39 (04) :523-528

[8] PARADOXICAL DECREASE OF BRAIN 5-HT TURNOVER BY METERGOLINE, A CENTRAL 5-HT RECEPTOR BLOCKER [J].

BOURGOIN, S ;

ARTAUD, F ;

BOCKAERT, J ;

HERY, F ;

GLOWINSKI, J ;

HAMON, M .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1978, 302 (03) :313-321

[9]

CHALMERS JP, 1975, CLIN EXPT PHARMACOLO, V2, P195

[10] CENTRAL SEROTONIN-LIKE ACTIVITY OF "6-CHLORO-2-[1-PIPERAZINYL]-PYRAZINE (CPP-MK-212) [J].

CLINESCHMIDT, BV ;

MCGUFFIN, JC ;

PFLUEGER, AB .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1977, 44 (01) :65-74

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