POSTNATAL-DEVELOPMENT OF ORNITHINE DECARBOXYLASE AND POLYAMINES IN THE MOUSE KIDNEY - INFLUENCE OF TESTOSTERONE

被引：0

作者：

SANCHEZCAPELO, A

PENAFIEL, R

TOVAR, A

GALINDO, JD

CREMADES, A

机构：

[1] UNIV MURCIA, FAC MED, DEPT BIOCHEM & MOLEC BIOL, E-30100 MURCIA, SPAIN

[2] UNIV MURCIA, FAC MED, DEPT PHARMACOL, E-30100 MURCIA, SPAIN

来源：

BIOLOGY OF THE NEONATE | 1994年 / 66卷 / 2-3期

关键词：

POLYAMINES; ORNITHINE DECARBOXYLASE; TESTOSTERONE; DEVELOPING MOUSE KIDNEY;

D O I：

暂无

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The role of ornithine decarboxylase (ODC) and polyamines in kidney growth during the postnatal development of mice and the influence of testosterone were investigated. A marked sexual dimorphism in renal size was evident after the 3rd week of life, corresponding with the rise in circulating testosterone and the increase in renal ODC and urinary excretion of putrescine in male mice. Renal putrescine and spermidine gradually decreased during the first 3 weeks of life and did not correlate with ODC activity. Treatments with alpha-difluoromethylornithine, and ODC-specific inhibitor, and the antiandrogen flutamide during weeks 4 and 5 showed that both compounds decreased renal ODC activity but only flutamide impaired kidney growth, suggesting that renal growth in mice is regulated by androgens but is independent of the induction of ODC activity.

引用

页码：119 / 127

页数：9

共 31 条

[21]

PEGG AE, 1988, CANCER RES, V48, P759

[22]

PEGG AE, 1988, ISI ATLAS-BIOCHEM, V1, P11

[23]

RAINA A, 1980, POLYAMINES BIOMEDICA, P35

[24] POLYAMINES IN DEVELOPING RAT AND IN SUPPORTIVE TISSUES [J].