ENHANCEMENT OF SUSCEPTIBILITY OF CB-17 MICE TO SYSTEMIC CANDIDIASIS BY POLY(I . C)-INDUCED INTERFERON

被引：7
作者：
JENSEN, J
BALISH, E
机构：
[1] UNIV WISCONSIN,SCH MED,DEPT SURG,1300 UNIV AVE,MADISON,WI 53706
[2] UNIV WISCONSIN,SCH MED,DEPT MED MICROBIOL & IMMUNOL,MADISON,WI 53706
来源：
INFECTION AND IMMUNITY | 1993年 / 61卷 / 08期
关键词：
D O I：
10.1128/IAI.61.8.3530-3532.1993
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Poly(I - C) enhanced the susceptibility of CB-17 (BALB/c) mice to acute systemic candidiasis. Poly(I . C), supernatants from poly(I - C)-treated macrophages, or alpha and beta interferons suppressed macrophage candidacidal activity in vitro. Thus, poly(I . C)-induced interferons may enhance the susceptibility of CB-17 mice to candidiasis by suppressing macrophage candidacidal activity in an autocrine fashion.
引用
收藏
页码：3530 / 3532
页数：3
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