Ethyl 7-methyl-2-((1-methyl-1H-pyrrol-2-yl) methylene)-3-oxo-5-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate

被引：2

作者：

Hu, Jie ^{[1
]}

Wu, Xi-Xi ^{[1
]}

Shen, Xue-Qian ^{[1
]}

Tang, Long-Guang ^{[1
]}

Li, Xiao-Kun ^{[1
]}

机构：

[1] Wenzhou Med Coll, Sch Pharm, Wenzhou 325035, Peoples R China

来源：

ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS | 2012年 / 68卷

关键词：

data-to-parameter ratio = 14.6; mean ̄(C-C) = 0.002 Å; R factor = 0.040; single-crystal X-ray study; T = 293 K; wR factor = 0.109;

D O I：

10.1107/S1600536812041748

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

In the structure of the title compound, C22H21N3O3S, the thiazole ring forms dihedral angles of 88.83 (7) and 9.39 (9)degrees, respectively, with the benzene and pyrrole rings. The dihydropyrimidine ring adopts a flattened boat conformation. The olefinic double bond is in a Z conformation.

引用

页码：O3099 / +

页数：8

共 13 条

[1] Convenient one pot synthesis of some novel derivatives of thiazolo[2,3-b]dihydropyrimidinone possessing 4-methylthiophenyl moiety and evaluation of their antibacterial and antifungal activities [J].

Ashok, Mithun ;

Holla, Bantwal Shivarama ;

Kumari, Nalilu Suchetha .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2007, 42 (03) :380-385

[2] Synthesis and anti-inflammatory activity of some [4,6-(4-substituted aryl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl]-acetic acid derivatives [J].

Bahekar, SS ;

Shinde, DB .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (07) :1733-1736

[3]

*BRUK AXS INC, 2002, SMART SAINT SADABS

[4] (2Z)-Ethyl 5-(4-methoxyphenyl)-7-methyl-3-oxo-2-(3,4,5-trimethoxybenzylidene)-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate [J].

Hou, Zhao-Hui .

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 :O235-U1359

[5] 2 NEW SYNTHETIC SUBSTANCES ACTIVE AGAINST VIRUSES OF PSITTACOSIS-LYMPHOGRANULOMA-TRACHOMA GROUP [J].

HURST, EW ;

HULL, R .

JOURNAL OF MEDICINAL & PHARMACEUTICAL CHEMISTRY, 1961, 3 (02) :215-&

[6] Synthesis and antioxidative properties of some 3,4-dihydropyrimidin-2(1H)ones (-thiones) [J].

Magerramov, A. M. ;

Kurbanova, M. M. ;

Abdinbekova, R. T. ;

Rzaeva, I. A. ;

Farzaliev, V. M. ;

Allakhverdiev, M. A. .

RUSSIAN JOURNAL OF APPLIED CHEMISTRY, 2006, 79 (05) :787-790

[7]

Mehta P. D., 2006, Indian Journal of Pharmaceutical Sciences, V68, P103

[8]

Pradhan, 2007, J PHARM RES, V6, P114

[9] Synthesis of some novel fluorinated 4-thiazolidinones containing amide linkages and their antimicrobial screening [J].

Shah, Tejaskumar J. ;

Desai, Vikas A. .

ARKIVOC, 2007, :218-228

[10] A short history of SHELX [J].

Sheldrick, George M. .

ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2008, 64 :112-122

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