DISTINCT LOCALIZATION OF COLLAGENASE AND TISSUE INHIBITOR OF METALLOPROTEINASES EXPRESSION IN WOUND-HEALING ASSOCIATED WITH ULCERATIVE PYOGENIC GRANULOMA

被引:138
作者
SAARIALHOKERE, UK
CHANG, ES
WELGUS, HG
PARKS, WC
机构
[1] WASHINGTON UNIV,JEWISH HOSP ST LOUIS,MED CTR,DIV DERMATOL,216 S KINGSHIGHWAY BLVD,ST LOUIS,MO 63110
[2] WASHINGTON UNIV,SCH MED,DEPT PATHOL,ST LOUIS,MO 63110
关键词
TISSUE INHIBITOR OF METALLOPROTEINASES; INTERSTITIAL COLLAGENASE; WOUND HEALING; KERATINOCYTES; PYOGENIC GRANULOMA;
D O I
10.1172/JCI116073
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
To examine the role of metalloproteinases in tissue remodeling associated with wound healing, we used in situ hybridization to localize the expression of collagenase and tissue inhibitor of metalloproteinases (TIMP) in samples of pyogenic granuloma. Strong hybridization for collagenase mRNA was detected in basal keratinocytes near the advancing edge of all ulcerative lesions, but no collagenase mRNA was seen in samples without ulceration. Distinct from the sites of collagenase expression, TIMP mRNA was detected in stromal cells and in cells surrounding proliferating vessels. No collagenase mRNA was found in the epidermis of healthy skin, although occasional stromal cells contained collagenase or TIMP mRNAs, and TIMP mRNA was detected in hair follicles and sebaceous glands. Our results suggest that basal keratinocytes adjacent to wounded epidermis are critically involved in matrix remodeling, much more so than adjacent or underlying dermal fibroblasts. Furthermore, as several reports have suggested, TIMP may play a role in angiogenesis. Finally, in contrast to findings from other models which indicate that collagenase and TIMP proteins are secreted by the same cells, our data also demonstrate that these proteins can be produced in vivo independently of each other.
引用
收藏
页码:1952 / 1957
页数:6
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