BIOSTATISTICAL MODELING OF THE EFFECT OF INTRAVENOUS HISTAMINE-INFUSION ON THE RAT GASTRIC-ACID SECRETION

被引：3

作者：

OZCELIKAY, AT ^{[1
]}

ALTINKURT, O ^{[1
]}

OZTURK, Y ^{[1
]}

YILDIZOGLUARI, N ^{[1
]}

ALTAN, VM ^{[1
]}

机构：

[1] UNIV ANKARA,FAC PHARM,ANKARA,TURKEY

来源：

JOURNAL OF PHARMACOLOGICAL METHODS | 1990年 / 24卷 / 03期

关键词：

Biostatistical modeling; Gastric acid secretion; Histamine; Linear regression; Parabolic regression; Polynomial regression;

D O I：

10.1016/0160-5402(90)90034-I

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this study, a variety of linear and nonlinear biostatistical models of regression were tested to evaluate the histamine-induced gastric acid secretion using the lumen-perfusion model in the rat. Among the linear, parabolic, and polynomial models tested, 3rd- and 4th-order polynomial models of regression exerted best correlations between the time and histamine-induced gastric acid secretion. In order to avoid undulatory behaviors in the regression curves, we conducted the polynomial regression analysis up to 5th order. © 1990.

引用

页码：241 / 250

页数：10

共 26 条

[1]

AMER SM, 1972, DIGEST DIS, V17, P945

[2] INFLUENCE OF SOME ANAESTHETICS ON PHARMACOLOGICALLY STIMULATED GASTRIC SECRETION IN RAT [J].