BIOSTATISTICAL MODELING OF THE EFFECT OF INTRAVENOUS HISTAMINE-INFUSION ON THE RAT GASTRIC-ACID SECRETION

被引：3
|
作者：
OZCELIKAY, AT [1 ]
ALTINKURT, O [1 ]
OZTURK, Y [1 ]
YILDIZOGLUARI, N [1 ]
ALTAN, VM [1 ]
机构：
[1] UNIV ANKARA,FAC PHARM,ANKARA,TURKEY
来源：
JOURNAL OF PHARMACOLOGICAL METHODS | 1990年 / 24卷 / 03期
关键词：
Biostatistical modeling; Gastric acid secretion; Histamine; Linear regression; Parabolic regression; Polynomial regression;
D O I：
10.1016/0160-5402(90)90034-I
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In this study, a variety of linear and nonlinear biostatistical models of regression were tested to evaluate the histamine-induced gastric acid secretion using the lumen-perfusion model in the rat. Among the linear, parabolic, and polynomial models tested, 3rd- and 4th-order polynomial models of regression exerted best correlations between the time and histamine-induced gastric acid secretion. In order to avoid undulatory behaviors in the regression curves, we conducted the polynomial regression analysis up to 5th order. © 1990.
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页码：241 / 250
页数：10
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