Ovarian germ cell tumour and bleomycin-induced lung injury

被引:0
作者
Barnardt, P. [1 ]
Griffith-Richards, S. [1 ]
机构
[1] Stellenbosch Univ, Dept Med Imaging & Clin Oncol MICO, Stellenbosch, South Africa
关键词
bleomycin; germ cell; lung toxicity; ovarian cancer;
D O I
10.1080/20742835.2018.1479213
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Bleomycin, an antibiotic agent with antitumour activity, is an important drug in the management of many oncological malignancies such as lymphoma and germ cell tumours. These tumours are potentially curable and mostly affect young people. The potential side effects and long-term toxicities should be considered. The major limitation of bleomycin therapy is pulmonary toxicity and may be life threatening in about 10% of cases. This article reports a case of an ovarian mixed germ cell tumour, which presented with bleomycin-associated pulmonary toxicity.
引用
收藏
页码:30 / 33
页数:4
相关论文
共 13 条
[1]   Germ cell tumors of the ovary: Is there a role for aggressive cytoreductive surgery for nondysgerminomatous tumors? [J].
Bafna, UD ;
Umadevi, K ;
Kumaran, C ;
Nagarathna, DS ;
Shashikala, P ;
Tanseem, R .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2001, 11 (04) :300-304
[2]   Germ Cell Tumors: Treatment Consensus Across All Age Groups Through MaGIC [Malignant Germ Cell International Collaborative] [J].
Hurteau, Jean A. ;
Febbraro, Terri .
CANCER, 2016, 122 (02) :181-183
[3]   REVERSAL OF BLEOMYCIN LUNG TOXICITY WITH CORTICOSTEROIDS [J].
KOZIELSKI, J .
THORAX, 1994, 49 (03) :290-290
[4]   THE ROLE OF CHEST COMPUTED-TOMOGRAPHY IN THE DIAGNOSIS OF DRUG-RELATED REACTIONS [J].
KUHLMAN, JE .
JOURNAL OF THORACIC IMAGING, 1991, 6 (01) :52-61
[5]   Pulmonary Function in Patients With Germ Cell Cancer Treated With Bleomycin, Etoposide, and Cisplatin [J].
Lauritsen, Jakob ;
Kier, Maria Gry Gundgaard ;
Bandak, Mikkel ;
Mortensen, Mette Sakso ;
Thomsen, Frederik Birkebaek ;
Mortensen, Jann ;
Daugaard, Gedske .
JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (13) :1492-+
[6]   SEVERE BLEOMYCIN LUNG TOXICITY - REVERSAL WITH HIGH-DOSE CORTICOSTEROIDS [J].
MAHER, J ;
DALY, PA .
THORAX, 1993, 48 (01) :92-94
[7]  
MILLS P, 1990, SEMIN ULTRASOUND CT, V11, P417
[8]   Malignant ovarian germ cell tumors: Identification of novel prognostic markers and long-term outcome after multimodality treatment [J].
Murugaesu, Nirupa ;
Schmid, Peter ;
Dancey, Gairin ;
Agarwal, Roshan ;
Holden, Lydia ;
McNeish, Iain ;
Savage, Philip M. ;
Newlands, Edward S. ;
Rustin, Gordon J. S. ;
Seckl, Michael J. .
JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (30) :4862-4866
[9]   Predicting the risk of bleomycin lung toxicity in patients with germ-cell tumours [J].
O'Sullivan, JM ;
Huddart, RA ;
Norman, AR ;
Nicholls, J ;
Dearnaley, DP ;
Horwich, A .
ANNALS OF ONCOLOGY, 2003, 14 (01) :91-96
[10]  
Reinert T., 2013, J CANCER RES CLIN, V2013, P480608, DOI [10.1155/2013/480608, DOI 10.1155/2013/480608]